- Total Layoffs: 50
- Total Employees: 20,534
| Company | Date | Location | # | % | Source |
| Daptiv | October 23, 2008 | Seattle | 21 | 14% | TechFlash |
| Avid Technology | October 23, 2008 | 500 | Yahoo Finance | ||
| WildTangent | October 23, 2008 | Redmond | 20 | 20% | TechFlash |
| Haute Secure | October 23, 2008 | Seattle | 3 | 50% | TechCrunch |
| XeroxCorp | October 23, 2008 | world-wide | 3,000 | 5% | WSJ |
| Cake Financial | October 23, 2008 | San Francisco, CA | 6 | 30% | internal blog |
| ManiaTV | October 22, 2008 | Los Angeles | 20 | 25% | NewTeeVee |
| Mercent | October 22, 2008 | Seattle | 6 | 12% | Seattle Times |
| Mahalo | October 22, 2008 | Santa Monica, CA | 6 | 10% | TechCrunch |
| Dell | October 22, 2008 | Round Rock, Texas | 8,900 | 10% | Reuters |
| imeem | October 22, 2008 | San Francisco, CA | 20 | 25% | TechCrunch |
| TicketMaster | October 22, 2008 | New York, NY | 300 | 5% | Billboard.biz |
| Timebridge | October 22, 2008 | San Francisco, CA | 9 | TechCrunch | |
| Manhattan Associates | October 21, 2008 | Across US | 150 | 6% | Reuters |
| Veoh | October 21, 2008 | St. Petersburg, Russia | 15 | Silicon Alley Insider | |
| Yahoo | October 21, 2008 | Sunnyvale, CA | 1,500 | 10% | TechCrunch |
| Veoh | October 20, 2008 | St. Petersburg, Russia | 15 | 12% | NewTeeVee |
| fon | October 20, 2008 | 40 | 40% | ||
| Eons | October 20, 2008 | Boston, MA | 8 | 24% | Boston Globe |
| Wikia | October 20, 2008 | San Mateo, California | 3 | 10% | TechCrunch |
| Meraki | October 20, 2008 | San Francisco, CA | 10 | 20% | TechCrunch |
| Break.com | October 20, 2008 | Los Angeles | 11 | 12% | CNet |
| Softchoice | October 20, 2008 | Across North America | 62 | 6% | The Star |
| Pandora | October 17, 2008 | Oakland, CA | 20 | TechCrunch | |
| Zillow | October 17, 2008 | Seattle, WA | 35 | TechCrunch | |
| SearchMe | October 17, 2008 | Mountain View, CA | 11 | 20% | VentureBeat |
| Heavy | October 17, 2008 | New York, NY | 12 | Silicon Alley Insider | |
| Jaxtr | October 17, 2008 | Menlo Park, CA | 13 | TechCrunch | |
| Appcelerator | October 17, 2008 | Atlanta, GA | 6 | CNET | |
| Sirius XM | October 17, 2008 | Washington, DC | 50 | CNET | |
| Adbrite | October 16, 2008 | San Francisco, CA | 40 | TechCrunch | |
| hi5 | October 16, 2008 | San Francisco, CA | 15 | 13% | TechCrunch |
| Zivity | October 16, 2008 | San Francisco, CA | 7 | TechCrunch | |
| Visto Corp | October 16, 2008 | 25 | 10% | The Register | |
| MPC | October 16, 2008 | Nampa ID and North Sioux City SD | 80 | 11% | Boise Channel 2 News |
| Tesla Motors | October 15, 2008 | San Carlos, CA | Tesla Motors | ||
| Jive Software | October 14, 2008 | Portland, OR | 40 | TechCrunch | |
| ClayValet | October 14, 2008 | Seattle | 3 | 99% | TechFlash |
| Qimonda | October 14, 2008 | Worldwide | 3,000 | 22% | Financial Times |
| Redfin | October 13, 2008 | Seattle, WA | 20 | 20% | Redfin |
| SuggestionBox | October 13, 2008 | San Diego | 7 | 87% | TechCrunch |
| Seesmic | October 10, 2008 | San Francisco, CA | 7 | TechCrunch | |
| Lulu | October 9, 2008 | Raleigh, NC | 24 | 24% | News & Observer |
| eBay | October 3, 2008 | San Jose, CA | 1,500 | 10% | TechCrunch |
| Gawker Media | October 3, 2008 | New York, NY | 19 | 14% | New York Times |
| Sony Ericsson | September 29, 2008 | RTP, NC | 450 | Triangle Buisness Journal | |
| Autobytel | September 26, 2008 | IRVINE, Calif | 75 | 33% | Kelsey Blog |
| NeoMagic Corporation | September 24, 2008 | Santa Clara | 90 | 90% | Bizjournals |
| Nvidia | September 18, 2008 | Santa Clara, CA | 360 | 6% | NetworkWorld |
