HolGenTech

HolGenTech leads the way in accelerating genome computing analysis with software addressing theapplications for a Genome Based Economy. The Silicon Valleybased company was founded on the basis of HoloGenomics: the synthesis of Genomics and Epigenomics expressedin Informatics calling for novel architectures of genome computing; see YouTube http://www.youtube.com/watch?v=mSRMCDCVg6Y. The company is currently engaged in securing Series A or angel funding for a rapid ignitionto ramp up implementation of the genome computing architecture. HolGenTech illustrates the practical application of the genome, emphasizing how personal genomeanalysis can be used as a tool for an individual to pursue all they can do to affect their genome. Disease prevention —or health—hinges on optimizing epigenomic pathways through foods, food additives, vitamins, cosmetics, chemicals, and environments to best fit or fix one’sgenome. The HolGenTech genome computing architecture — where a handheld application utilizes any PDA to become the Personal Genome Assistant (PGA), representing a mobile component of the HolGenTech genome computing architecture - utilizes high performance parallelcomputing for genome analysis to search for both conventional structuralvariants and proprietary search of fractal defects, making the genomepractically usable for consumers who want to make their best choices for living.

Andras J. Pellionisz- bio

Founder of HolGenTechnologies  [email protected] 

An era of affordable DNAsequencing is here. With it comes emphasis on IT based actionable interpretation of the genome, and a new time of opportunity similar to “Digital”emerges. It is important to emphasize that both interpretation of full genomes and utilization of those results will and must be automated. The opportunity now is to establish a business ecosystem that channels top science into automation within a model where real customers benefit immediately andsufficiently to sustain economic viability within that model. Recently, TechNewsWorld stated, "Don't look now, but we may be about toenter the genome based economy."  HolGenTech leverages existing high performance computing hardware and introduces software architecture based on custom algorithms and better science to accelerate aGenome Based Economy. Genomes must be treated as data to deliver practical results from both genomic testing of partial DNA information and for full analysis of whole genome sequences. HolGenTech is based on analyzing the overwhelming amounts of data that results from a coming onslaught of personal genome sequencing; without fast analysis, the industry is unsustainable. HolGenTech is set to put a practical tool in the consumer’s hand, delivering health based on personal genome information through a broad-based consumerism model. With HolGenTech’s proprietary architecture for Genome Computing, the Company analyzes genomes for real utility and individual consumer benefit.  VisionThe fulcrum of the unfolding Genome Based Economy is certainly Genome Computing. DNA essentially presents a computing problem, though ill-prepared approaches taken todate have been fraught with unresolved privacy and/or regulatory issues and/or hardware-software compute problems.

In contrast, HolGenTech sees an easy opportunity that transcends prevailing obstacles by using existing Direct-to-Customer (DTC) models for genome testing and completing them with analysis and tools for customer use. DTC business models of prevention, such as 23andMe and Navigenics know what they lack. Customers of these businesses own their genomes, but they can’t use them in practical daily application. The companies deliver marker analysis, usually in the form of ashort list of observations or advice, and in raw data files suitable forautomated use – and to what HolGenTech proposes. Advice can be vague, and file information—while easily downloaded—is not easily interpreted for actionable use. So, customers lack the power and information of their personal genome indaily decision making, when shopping or cooking, for example. Using a PDA transformed to a PGA — Personal Genome Assistant—HolGenTech equips consumers with an automated tool that makes recommendation based ontheir personal genome. HolGenTech empowers consumers with PGAs for the GenomeBased Economy of the 21^st century. In this fast track, there is no waitingfor next generation genomics, or complete interpretation of full genomes, or forregulatory/legal hurdles to be overcome. We see the PGA-equipped consumers making the Genome Based Economy immediate, and pushing innovation inthe category, as they are both ready for and expectant of new features from theGenome Based Economy, just as cell phone users await next developments.  Note the full demo of Shop for Your Life on YouTube -- in the side bar here there is only a low resolution and abbreviated copy of the full version available at:  

http://www.youtube.com/watch?v=mSRMCDCVg6Y

 

HolGenTech assesses acompetitive advantage over existing large Centers (BCM,Broad Inst, U-Wash, Wash-U, BGI, CGI,PacBio, JGI etc), in that a nimble start-up, based on proprietary IP,strategically placed both by geography and in the private domain is preferablewhen the large industry-wide adoption comes and the category incurs much highervaluation. Tracks leading to a dependency on a single sequencer or targeting a narrowmarket segment are to be avoided. Government anduniversity-based solutions are not generally suitable to spur rapid ramp-up foran emerging private industry or a paradigm shift for an existing one. Universitysoftware is known to lag as students graduate. An unencumbered,rapidly ignited Silicon Valley company iseminently suited to accelerate coalescing disparate industries—IT and Genomics—andachieve resonance.